Decreased bone mineral density in patients with neurofibromatosis 1

  title={Decreased bone mineral density in patients with neurofibromatosis 1},
  author={Marga Lammert and Martin Kappler and V Mautner and Kurt Lammert and Stephan Stoerkel and Jan M Friedman and Derek John Atkins},
  journal={Osteoporosis International},
Neurofibromatosis 1 (NF1) is one of the most common autosomal dominant diseases. Although there is a considerable variability in clinical expression, NF1 is almost fully penetrant in adult patients and may be associated with a variety of skeletal anomalies. Spinal deformities are the most common skeletal manifestation, with an incidence estimated from 10–25% in various studies. Some NF1 patients have a dystrophic form of scoliosis, which is characterized by early age at onset and rapid… CONTINUE READING


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Generalized osteopenia in neurofibromatosis type 1 patients points to an underlying disorder of skeletal homeostasis and mineralization

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