Decreased bone mineral density in HLA-B27 positive members of a family with osteogenesis imperfecta.

@article{Escalante1993DecreasedBM,
  title={Decreased bone mineral density in HLA-B27 positive members of a family with osteogenesis imperfecta.},
  author={Agustin Alvarez Escalante and Tannis Beardmore},
  journal={The Journal of rheumatology},
  year={1993},
  volume={20 2},
  pages={320-4}
}
We describe a family in which several members had osteogenesis imperfecta (OI) and/or were positive for HLA-B27. The proband, who had ankylosing spondylitis and OI, had severe osteoporosis with fractures continuing to occur in the late teens. Bone mineral density measurements in 5 family members and the proband, revealed more severe osteoporosis in those… CONTINUE READING