Decreased blood pressure in NOX1-deficient mice.

  title={Decreased blood pressure in NOX1-deficient mice.},
  author={Ga{\"e}tan Gavazzi and Botond B{\'a}nfi and Christine Deffert and Laurence Fiette and Michela Schappi and François R Herrmann and K Krause},
  journal={FEBS letters},
  volume={580 2},
To understand the role of the superoxide-generating NADPH oxidase NOX1 in the vascular system, we have generated NOX1-deficient mice. NOX1-deficient mice had a moderately decreased basal blood pressure. In response to angiotensin II they showed an almost complete loss of the sustained blood pressure response, while the initial increase was conserved. NOX1-deficient mice showed a marked reduction in aortic media hypertrophy. Angiotensin II-induced smooth muscle cell proliferation was conserved… CONTINUE READING
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Functional analysis of Nox4 reveals unique characteristics compared to other NADPH oxidases

  • K. D. Martyn, L. M. Frederick, K. von Loehneysen, M. C. Dinauer, U. G. Knaus
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