Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease.

@article{Boileau2009DecreasedBO,
  title={Decreased binding of the D3 dopamine receptor-preferring ligand [11C]-(+)-PHNO in drug-naive Parkinson's disease.},
  author={Isabelle Boileau and Mark Guttman and Pablo M Rusjan and John R. Adams and Sylvain Houle and Junchao Tong and Oleh Hornykiewicz and Yoshiaki Furukawa and Alan A. Wilson and Shitij Kapur and Stephen J. Kish},
  journal={Brain : a journal of neurology},
  year={2009},
  volume={132 Pt 5},
  pages={1366-75}
}
The D(3) dopamine (DA) receptor is a member of the D(2)-like DA receptor family. While the D(2) receptor is abundant especially in motor-regions of the striatum, the D(3) receptor shows a relative abundance in limbic regions and globus pallidus. This receptor is of current interest in neurology because of its potential involvement in psychiatric and motor complications in Parkinson's disease and the possibility that dopamine D(3)-preferring agonist therapy might delay progression of the… CONTINUE READING
26 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 26 extracted citations

Similar Papers

Loading similar papers…