Decreased biliary glutathione content is responsible for the decline in bile salt-independent flow induced by ethinyl estradiol in rats.

@article{Bouchard1994DecreasedBG,
  title={Decreased biliary glutathione content is responsible for the decline in bile salt-independent flow induced by ethinyl estradiol in rats.},
  author={G{\'e}rard Bouchard and Ibrahim M. Yousef and Beatriz Tuchweber},
  journal={Toxicology letters},
  year={1994},
  volume={74 3},
  pages={221-33}
}
Glutathione appears to be a major osmotic factor in the generation of bile salt-independent flow (BSIF). This study was designed to investigate its importance in the pathology of 17-alpha-ethinyl estradiol (EE)-induced cholestasis. Five-day EE treatment at the dose level of 5 mg/kg/day significantly decreased bile flow (57% of controls) and biliary… CONTINUE READING