Decreased basal insulin secretion from pancreatic islets of pups in a rat model of maternal obesity.

@article{Zambrano2016DecreasedBI,
  title={Decreased basal insulin secretion from pancreatic islets of pups in a rat model of maternal obesity.},
  author={Elena Zambrano and Tonantzin C Sosa-Larios and Lizbeth Calzada and Carlos A. Ib{\'a}{\~n}ez and C. Adriana Mendoza-rodr{\'i}guez and Ang{\'e}lica Morales and S Morimoto},
  journal={The Journal of endocrinology},
  year={2016},
  volume={231 1},
  pages={
          49-57
        }
}
Maternal obesity (MO) is a deleterious condition that enhances susceptibility of adult offspring to metabolic diseases such as type 2 diabetes. The objective is to study the effect of MO on in vitro insulin secretion and pancreatic cellular population in offspring. We hypothesize that a harmful antenatal metabolic environment due to MO diminishes the basal glucose-responsive secretory function of pancreatic beta cells in offspring. Mothers were fed a control (C) or high-fat diet from weaning… CONTINUE READING
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