Decreased basal chloride secretion and altered cystic fibrosis transmembrane conductance regulatory protein, Villin, GLUT5 protein expression in jejunum from leptin-deficient mice

@inproceedings{Leung2014DecreasedBC,
  title={Decreased basal chloride secretion and altered cystic fibrosis transmembrane conductance regulatory protein, Villin, GLUT5 protein expression in jejunum from leptin-deficient mice},
  author={Lana Leung and Jonathan Kang and Esa Rayyan and Ashesh Bhakta and Brennan Barrett and D. Larsen and Ryan Jelinek and Justin D Willey and Scott Cochran and Tom L Broderick and Layla Al-Nakkash},
  booktitle={Diabetes, metabolic syndrome and obesity : targets and therapy},
  year={2014}
}
Patients with diabetes and obesity are at increased risk of developing disturbances in intestinal function. In this study, we characterized jejunal function in the clinically relevant leptin-deficient ob/ob mouse, a model of diabetes and obesity. We measured transepithelial short circuit current (Isc), across freshly isolated segments of jejunum from 12-week-old ob/ob and lean C57BL/6J (female and male) mice. The basal Isc was significantly decreased (~30%) in the ob/ob mice (66.5±5.7 μA/cm(2… CONTINUE READING

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