Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice.

  title={Decreased basal, noninsulin-stimulated glucose uptake and metabolism by skeletal soleus muscle isolated from obese-hyperglycemic (ob/ob) mice.},
  author={Guy S Cuendet and Ernest G Loten and Bernard Jeanrenaud and Albert E. Renold},
  journal={The Journal of clinical investigation},
  volume={58 5},
Insulin resistance of diaphragms of ob/ob mice has been repeatedly demonstrated previously both in vitro and in vivo. In the present study, transport and metabolism of glucose with and without insulin stimulation were compared in a skeletal muscle more likely than diaphragm or heart to be representative of the overall striated muscle mass, i.e. isolated soleus muscle. Compared with soleus muscle from lean controls, unstimulated lactate release in the presence of exogenous glucose was depressed… CONTINUE READING

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Hormone - substrate responses to total fastinig in lean anid obese imjce

W. Stauiffaclher, D. V'ecechio A. E. Lambert, atd A. E. Renold
Ain . J . Physiol . • 1975

Instulin resistance of parabiotic obese - hyperglycemic mice ( oblob )

P. R. Johnson, R. J. Mlahler
Hormiz . Metab . Res . • 1975

Regulation of heart muscle pyruvate dehydloge nase kinase

G. S. Ctuendet, E. G. Loten, D. P. Camiieron, A. E. Renold, E. B. Marliss
Biochem . J . • 1974

Impairmenit of insulin binding to the fat cell membrane in the obese hyperglycemic m nouse

Jr. D. NI. Neville, anlid J. Rotlh
FEBS ( Fed . Elo . Bioc / lmen . Soc . ) Lett . • 1973

Instulin resistance of the ilnherently obese motise - ob ob . Natuire ( Lond . )

D. L Colemani

Hormonal control of intermediary metabolism in obese - hy per - glvcemic mice . I . The sensitivitv anid response to instulin in adipose tisstue and mulscle in vitro

C Chlouiverakis
Diabetes . • 1972

Spontanieouis hyperglycemnia anid / or obesity in laboratory rodents : anl examiiple of the possible usefuilness of aiiinial disease models ' with both genetic anid environmental comiiponients

P. Freychet, P. Latudat MI. H. Latudat, +3 authors J. Roth
Recent Prog . Horni . Res . • 1972

Stuidies on the metabolic effects induced in the rat by a high - fat diet . Inhibition of pyruvate metabolism in diaphragm in vitro and its relation to the oxida - tioIn of fatty acids

P. J. Ranidle
Eir . J . Biochlieni • 1972

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