Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease

@article{ChenPlotkin2006DecreasedAO,
  title={Decreased association of the transcription factor Sp1 with genes downregulated in Huntington's disease},
  author={A. Chen-Plotkin and G. Sadri-Vakili and G. Yohrling and Melissa W. Braveman and C. Benn and Kelly E. Glajch and Derek P. DiRocco and L. Farrell and D. Krainc and S. Gin{\'e}s and M. MacDonald and J. Cha},
  journal={Neurobiology of Disease},
  year={2006},
  volume={22},
  pages={233-241}
}
Huntington's disease (HD) is a neurodegenerative disease caused by expansion of a polyglutamine tract within the huntingtin protein. Transcriptional dysregulation has been implicated in HD pathogenesis; recent evidence suggests a defect in Sp1-mediated transcription. We used chromatin immunoprecipitation (ChIP) assays followed by real-time PCR to quantify the association of Sp1 with individual genes. We find that, despite normal protein levels and normal to increased overall nuclear binding… Expand
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