Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

  title={Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice},
  author={K. Kuida and T. Zheng and S. Na and C. Kuan and D. Yang and H. Karasuyama and P. Rakic and R. Flavell},
  • K. Kuida, T. Zheng, +5 authors R. Flavell
  • Published 1996
  • Biology, Medicine
  • Nature
  • PROGRAMMED cell death (apoptosis) is a prominent feature of the development of the immune and nervous systems1,2. The identification of the Caenorhabditis elegans cell death gene, ced-3, as a prototype of the interleukin-lβ converting enzyme (ICE) protease family has led to extensive evidence implicating these enzymes in apoptosis3,4. Among the ten or more members of the ICE protease family, CPP32/yama/apopain5–7 exhibits the highest similarity to CED-3 in both sequence homology and substrate… CONTINUE READING
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