• DOI:10.1038/384368A0
Corpus ID: 4353931

Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice

@article{Kuida1996DecreasedAI,
  title={Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice},
  author={K. Kuida and T. Zheng and S. Na and C. Kuan and D. Yang and H. Karasuyama and P. Rakic and R. Flavell},
  journal={Nature},
  year={1996},
  volume={384},
  pages={368-372}
}

K. Kuida, T. Zheng, +5 authors R. Flavell

Published 1996

Biology, Medicine

Nature

PROGRAMMED cell death (apoptosis) is a prominent feature of the development of the immune and nervous systems1,2. The identification of the Caenorhabditis elegans cell death gene, ced-3, as a prototype of the interleukin-lβ converting enzyme (ICE) protease family has led to extensive evidence implicating these enzymes in apoptosis3,4. Among the ten or more members of the ICE protease family, CPP32/yama/apopain5–7 exhibits the highest similarity to CED-3 in both sequence homology and substrate… CONTINUE READING

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