Decreased alveolarization in baboon survivors with bronchopulmonary dysplasia.

  title={Decreased alveolarization in baboon survivors with bronchopulmonary dysplasia.},
  author={Jacqueline J. Coalson and Viktor Winter and Robert A Delemos},
  journal={American journal of respiratory and critical care medicine},
  volume={152 2},
In this study, 12 male baboons were delivered by hysterotomy at 75% of gestation. The development of a nonlethal baboon model permitted a study of lung growth and development in long-term survivors. Control animals were ventilated with clinically appropriate oxygen for the 21 d study period. BPD animals were ventilated with PPV and an FIO2 of 1.0 for 7 d, followed by an FIO2 of 0.8 for 14 d. They survived for 33 wk, at which time a right lower lobe lobectomy was performed. Controls showed… CONTINUE READING
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