Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats

@article{Santoru2014DecreasedAI,
  title={Decreased allopregnanolone induced by hormonal contraceptives is associated with a reduction in social behavior and sexual motivation in female rats},
  author={F. Santoru and R. Berretti and A. Locci and P. Porcu and A. Concas},
  journal={Psychopharmacology},
  year={2014},
  volume={231},
  pages={3351-3364}
}
  • F. Santoru, R. Berretti, +2 authors A. Concas
  • Published 2014
  • Psychology, Medicine
  • Psychopharmacology
  • RationaleAllopregnanolone is a neurosteroid involved in depression, memory, social, and sexual behavior. We have previously demonstrated that treatment with a combination of ethinylestradiol (EE) and levonorgestrel (LNG), two compounds frequently used in hormonal contraception, decreased brain allopregnanolone concentrations. These changes may contribute to some of the emotional and sexual disorders observed in hormonal contraceptive users.ObjectivesWe thus examined whether the reduction in… CONTINUE READING
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