Decreased agglutinability of human erythrocytes by attachment of methoxy polyethylene glycol and the effect on erythrocyte oxygen-carrying ability.


In the interest of creating readily transfusable blood, we have developed a method of covalently bonding methoxy polyethylene gylcol (mPEG) to the erythrocyte membrane to mask antigens which would otherwise cause immunorejection in unmatched blood transfusions. Previous studies have reported the ability of mPEG to mask erythrocyte antigens without… (More)