Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.

@article{Btkai2007DecreasedAC,
  title={Decreased age-related cardiac dysfunction, myocardial nitrative stress, inflammatory gene expression, and apoptosis in mice lacking fatty acid amide hydrolase.},
  author={S{\'a}ndor B{\'a}tkai and Mohanraj Rajesh and Partha Mukhopadhyay and Gy{\"o}rgy Hask{\'o} and Lucas Liaudet and Benjamin F Cravatt and Anna Csisz{\'a}r and Zoltan Ungvari and P{\'a}l Pacher},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 2},
  pages={H909-18}
}
Recent studies have uncovered important cross talk between inflammation, generation of reactive oxygen and nitrogen species, and lipid metabolism in the pathogenesis of cardiovascular aging. Inhibition of the endocannabinoid anandamide metabolizing enzyme, the fatty acid amide hydrolase (FAAH), is emerging as a promising novel approach for the treatment of various inflammatory disorders. In this study, we have investigated the age-associated decline of cardiac function and changes in… CONTINUE READING
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