Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment.

@article{Carpenter2007DecreasedAH,
  title={Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment.},
  author={Linda L Carpenter and John P. Carvalho and Audrey R. Tyrka and Lauren M Wier and Andrea de Abreu Feij{\'o} de Mello and Marcelo Feij{\'o} de Mello and George M See Anderson and Charles W Wilkinson and Lawrence H. Price},
  journal={Biological psychiatry},
  year={2007},
  volume={62 10},
  pages={1080-7}
}
BACKGROUND Preclinical research findings suggest that exposure to stress and concomitant hypothalamus-pituitary-adrenal (HPA) axis activation during early development can have permanent and potentially deleterious effects. A history of early-life abuse or neglect appears to increase risk for mood and anxiety disorders. Abnormal HPA response to stress challenge has been reported in adult patients with major depressive disorder and posttraumatic stress disorder. METHODS Plasma… CONTINUE READING
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