Decreased activity of gastric class III (χ) ADH can explain increased bioavailability of alcohol in women

@inproceedings{Baraona1998DecreasedAO,
  title={Decreased activity of gastric class III (χ) ADH can explain increased bioavailability of alcohol in women},
  author={Enrique Baraona and Kazufumi Dohmen and G. Pazzato and Charles S. Lieber},
  year={1998}
}
Women are more vulnerable than men to alcohol-induced diseases. This could be due to their higher blood levels. No comparable effect was observed after i.v. administration, suggesting an increased bioavailability of the imbibed alcohol. Furthermore, below the age of 50, this effect was associated with a decrease in total gastric ADH activity, rather than with a lesser rate of ethanol elimination, which in fact may be increased in women. To quantify the difference in bioavailability, the amount… CONTINUE READING