Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia-reperfusion injury.

  title={Decreased abundance of urinary exosomal aquaporin-1 in renal ischemia-reperfusion injury.},
  author={Hiroko Sonoda and Naoko Yokota-Ikeda and Sayaka Oshikawa and Yosuke Kanno and Kazuya Yoshinaga and Kazuyuki Uchida and Yuuji Ueda and Kouichi Kimiya and Shigehiro Uezono and Akira Ueda and Katsuaki Ito and Masahiro Ikeda},
  journal={American journal of physiology. Renal physiology},
  volume={297 4},
Urinary exosomes, secreted into urine from renal epithelial cells, are known to contain many types of renal functional membrane proteins. Here, we studied whether renal ischemia-reperfusion (I/R) affects urinary exosomal aquaporin-1 (AQP1) excretion in rats subjected to renal I/R and patients who underwent renal transplantation. Immunoblotting studies demonstrated reduction of the urinary exosomal AQP1 level even at 6 h after renal I/R, and the level continued to be low over 96 h after I/R… 

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