Decreased absorption as a possible cause for the lower bioavailability of a sustained-release propranolol.

@article{Takahashi1990DecreasedAA,
  title={Decreased absorption as a possible cause for the lower bioavailability of a sustained-release propranolol.},
  author={Harumi Takahashi and Hiroyasu Ogata and R Warabioka and Kouji Kashiwada and Masayoshi Ohira and Kazuhiko Someya},
  journal={Journal of pharmaceutical sciences},
  year={1990},
  volume={79 3},
  pages={212-5}
}
The influence of sustained absorption on the oral availability of propranolol (P) and the metabolic disposition of P were investigated by obtaining the partial metabolic clearances (CLm) following long-acting P (LA) dosing in comparison with the conventional propranolol tablet (CP). Ten healthy volunteers were given a single oral dose of an LA capsule (60 mg) and CP (20 mg x 3) using a crossover design. Blood and urine samples were collected over 24- and 48-h postdose periods, respectively… CONTINUE READING