Decreased Uptake of Glucose by Human Forearm During Infusion of Leucine, Isoleucine, or Threonine

@article{Schwenk1987DecreasedUO,
  title={Decreased Uptake of Glucose by Human Forearm During Infusion of Leucine, Isoleucine, or Threonine},
  author={W. Schwenk and M. Haymond},
  journal={Diabetes},
  year={1987},
  volume={36},
  pages={199 - 204}
}
Competition between glucose and free fatty acids as metabolic fuels is supported by both in vitro and in vivo data, but whether amino acids can also compete with glucose as a source of energy in vivo remains to be established. To determine the effect of increased availability of an amino acid on whole-body glucose flux and glucose carbon uptake by the human forearm, five groups of overnight-fasted normal subjects were infused with either saline, leucine (at 0.5 or 1.0μmol · kg−1 · min−1… Expand
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