Decreased Survival of B Cells of HIV-viremic Patients Mediated by Altered Expression of Receptors of the TNF Superfamily

@article{Moir2004DecreasedSO,
  title={Decreased Survival of B Cells of HIV-viremic Patients Mediated by Altered Expression of Receptors of the TNF Superfamily},
  author={Susan Moir and Angela Malaspina and Oxana K. Pickeral and Eileen T. Donoghue and Joshua Vasquez and Natalie J. Miller and Surekha R. Krishnan and Marie A. Planta and John F. Turney and Jesse S. Justement and Shyamasundaran Kottilil and Mark Dybul and Joann M Mican and Colin M. Kovacs and Tae-Wook Chun and Charles E. Birse and Anthony S. Fauci},
  journal={The Journal of Experimental Medicine},
  year={2004},
  volume={200},
  pages={587 - 600}
}
Human immunodeficiency virus (HIV) infection leads to numerous perturbations of B cells through mechanisms that remain elusive. We performed DNA microarray, phenotypic, and functional analyses in an effort to elucidate mechanisms of B cell perturbation associated with ongoing HIV replication. 42 genes were up-regulated in B cells of HIV-viremic patients when compared with HIV-aviremic and HIV-negative patients, the majority of which were interferon (IFN)-stimulated or associated with terminal… CONTINUE READING