Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1.

@article{Jiang1999DecreasedRE,
  title={Decreased RIZ1 expression but not RIZ2 in hepatoma and suppression of hepatoma tumorigenicity by RIZ1.},
  author={Guoqiang Jiang and Limin Liu and I M Buyse and Dagmar Simon and Shile Huang},
  journal={International journal of cancer},
  year={1999},
  volume={83 4},
  pages={541-6}
}
The distal short arm of human chromosome 1 (1p36) is commonly altered in primary hepatoma tumors and cell lines. This region includes the RIZ gene, a member of the PR (PRDI-BF1/BLIMP1 and RIZ homology) domain family of transcription factors. An unusual feature of this family is the yin-yang involvement in human cancers. Two products are normally produced from a PR family member which differ by the presence or absence of the PR domain; the PR-plus product is disrupted or underexpressed whereas… CONTINUE READING
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