Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration.

  title={Decreased PDH activation and glycogenolysis during exercise following fat adaptation with carbohydrate restoration.},
  author={Trent Stellingwerff and Lawrence L. Spriet and Matthew J. Watt and Nicholas E. Kimber and Mark Hargreaves and John A. Hawley and Louise M. Burke},
  journal={American journal of physiology. Endocrinology and metabolism},
  volume={290 2},
Five days of a high-fat diet while training, followed by 1 day of carbohydrate (CHO) restoration, increases rates of whole body fat oxidation and decreases CHO oxidation during aerobic cycling. The mechanisms responsible for these shifts in fuel oxidation are unknown but involve up- and downregulation of key regulatory enzymes in the pathways of skeletal muscle fat and CHO metabolism, respectively. This study measured muscle PDH and HSL activities before and after 20 min of cycling at 70… 

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