Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia.

@article{Barakat2010DecreasedN1,
  title={Decreased Neuregulin 1 C-terminal fragment in Brodmann's area 6 of patients with schizophrenia.},
  author={Adel Barakat and Brian Dean and Elizabeth Scarr and Genevieve Evin},
  journal={Schizophrenia research},
  year={2010},
  volume={124 1-3},
  pages={200-7}
}
Neuregulin 1 (NRG1) is a susceptibility gene for schizophrenia. A decrease in NRG1-ErbB4 signalling has also been associated with the disease. β-amyloid precursor protein-cleaving enzyme (BACE1) processes type III NRG1 precursor, a major neuregulin variant expressed in the brain, to release NRG1 fragments that trigger signalling events and activation of neurotransmitter receptors. Experimental evidence suggests that muscarinic acetylcholine receptors (CHRM) regulate BACE1 expression. Having… CONTINUE READING

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