Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease.

@article{Brass2001DecreasedND,
  title={Decreased NADH dehydrogenase and ubiquinol-cytochrome c oxidoreductase in peripheral arterial disease.},
  author={Eric P. Brass and William Robert Hiatt and Andrew W Gardner and Charles L. Hoppel},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2001},
  volume={280 2},
  pages={H603-9}
}
Peripheral arterial disease (PAD) is associated with muscle metabolic changes that may contribute to the disability in these patients. However, the biochemical defects in PAD have not been identified. The present study was undertaken to test the hypothesis that PAD is associated with specific defects in skeletal muscle electron transport chain activity. Seventeen patients with PAD and nine age-matched controls underwent gastrocnemius muscle biopsies. There were no differences in the… CONTINUE READING
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