Decreased Mdm2 expression inhibits tumor development induced by loss of ARF

@article{Wang2006DecreasedME,
  title={Decreased Mdm2 expression inhibits tumor development induced by loss of ARF},
  author={Peng Wang and Timothy Charles Greiner and Tamara Lushnikova and Christine M. Eischen},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={3708-3718}
}
The tumor suppressor p14/p19ARF regulates Mdm2, which is known for controlling the p53 tumor suppressor. Here we report that loss of one allele of Mdm2 in cells that lack ARF resulted in a decreased rate of proliferation, fewer chromosomal aberrations, and suppression of Ras-induced transformation. Moreover, a haploinsufficiency of Mdm2 inhibited spontaneous tumor development in ARF-null mice. Remarkably, Mdm2+/−ARF−/− mice survived an average of 6 months longer than Mdm2+/+ARF−/− mice. The… CONTINUE READING
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