Decreased Joint Tissue Damage Less Joint Inflammation Decreased PAIN Improved Mobility Increased Muscular Strength Improved Body Composition Less Disability Improved Physical Function Intensive Dietary Induced Weight Loss ± Exercise for Symptomatic Knee OA PrimaryOutcome Primary Outcome Decreased Jo

@inproceedings{Messier2009DecreasedJT,
  title={Decreased Joint Tissue Damage Less Joint Inflammation Decreased PAIN Improved Mobility Increased Muscular Strength Improved Body Composition Less Disability Improved Physical Function Intensive Dietary Induced Weight Loss ± Exercise for Symptomatic Knee OA PrimaryOutcome Primary Outcome Decreased Jo},
  author={Stephen P. Messier and Claudine Legault and Shannon L. Mihalko and Gary D. Miller and Richard F. Loeser and Paul Devita and Mary F. Lyles and Felix Eckstein and David J. Hunter and Jeff D. Williamson and Barbara J Nicklas},
  year={2009}
}
Background: Obesity is the most modifiable risk factor, and dietary induced weight loss potentially the best nonpharmacologic intervention to prevent or to slow osteoarthritis (OA) disease progression. We are currently conducting a study to test the hypothesis that intensive weight loss will reduce inflammation and joint loads sufficiently to alter disease progression, either with or without exercise. This article describes the intervention, the empirical evidence to support it, and test-retest… CONTINUE READING

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