Decreased Interleukin-12 ( IL-12 ) From Activated Cord Versus Adult Peripheral Blood Mononuclear Cells and Upregulation of Interferon-? , Natural Killer , and Lymphokine-Activated Killer Activity by IL-12 in Cord Blood Mononuclear Cells

@inproceedings{Qian2002DecreasedI,
  title={Decreased Interleukin-12 ( IL-12 ) From Activated Cord Versus Adult Peripheral Blood Mononuclear Cells and Upregulation of Interferon-? , Natural Killer , and Lymphokine-Activated Killer Activity by IL-12 in Cord Blood Mononuclear Cells},
  author={John Qian},
  year={2002}
}
Interleukin-12 (IL-12) is a critical cytokine regulating natural killer (NK) and T-cell function. We hypothesized that the impaired a b i l i of cord blood (CBI to produce normal adult levels of 11-12 in response to stimulation may contribute to the immaturity of CB immunity. Furthermore, exogenous IL12 may compensate for the immaturity in CB cellular immunity and have the potential for immunotherapy post cord blood transplantation. We compared the expression and production of IL-12 from… CONTINUE READING