Decreased Hypothalamic Glucagon-Like Peptide-1 Receptor Expression in Type 2 Diabetes Patients.

  title={Decreased Hypothalamic Glucagon-Like Peptide-1 Receptor Expression in Type 2 Diabetes Patients.},
  author={Jennifer S Ten Kulve and L van Bloemendaal and Rawien A Balesar and Richard G. Ijzerman and Dick F. Swaab and Michaela Diamant and Susanne E la Fleur and Anneke Alkemade},
  journal={The Journal of clinical endocrinology and metabolism},
  volume={101 5},
CONTEXT Glucagon-like peptide-1 (GLP-1) and GLP-1 receptor agonist treatment in type 2 diabetes (T2DM) reduce blood glucose and food intake. It has been suggested that these effects are partly mediated through central GLP-1 receptors (GLP-1Rs). The rodent and nonhuman primate hypothalamus show clear GLP-1R expression. However, a detailed description of GLP-1R expression in the human hypothalamus is lacking, and it is unknown whether this expression is altered in T2DM patients. OBJECTIVE The… CONTINUE READING
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