Decreased HIV-associated T cell apoptosis by HIV protease inhibitors.

@article{Phenix2000DecreasedHT,
  title={Decreased HIV-associated T cell apoptosis by HIV protease inhibitors.},
  author={Barbara N Phenix and Jonathan Angel and Frank F Mandy and Stephen Kravcik and Karl G Parato and Kelley A Chambers and Keith Gallicano and Nanci C Hawley-Foss and Sharon Cassol and D William Cameron and Andrew D Badley},
  journal={AIDS research and human retroviruses},
  year={2000},
  volume={16 6},
  pages={559-67}
}
Antiretroviral treatment of patients infected with HIV results in improvements in CD4+ T cell number. Emerging evidence suggests that some of the improvements in CD4+ T cell number that occur in response to protease inhibitor (PI) therapy may not be accounted for solely by enhanced viral suppression, implying that PI may directly affect T cell survival. Since HIV T cell depletion is associated with enhanced apoptosis, we analyzed the effect of PIs on T cell apoptosis. In vitro treatment of… CONTINUE READING