Decreased GlcNAc 6-O-sulfotransferase activity in the cornea with macular corneal dystrophy.

@article{Hasegawa2000DecreasedG6,
  title={Decreased GlcNAc 6-O-sulfotransferase activity in the cornea with macular corneal dystrophy.},
  author={Nobuko Hasegawa and Tomohiro Torii and Takahisa Kato and Hiroaki Miyajima and Atushi Furuhata and Kiyoo Nakayasu and A. Kanai and Osami Habuchi},
  journal={Investigative ophthalmology & visual science},
  year={2000},
  volume={41 12},
  pages={
          3670-7
        }
}
PURPOSE Macular corneal dystrophy (MCD) is an autosomal recessive inherited disorder that is accompanied by corneal opacity. Explants from MCD-affected corneas have been reported to synthesize low-sulfated KS, suggesting that sulfate groups attached to KS may play critical roles in maintaining corneal transparency. To clear the biosynthetic defect in the MCD cornea, sulfotransferase activities were determined that are presumably involved in the biosynthesis of KS: galactose-6-sulfotransferase… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 16 CITATIONS

Novel mutations in the CHST6 gene associated with macular corneal dystrophy in southern India.

  • Archives of ophthalmology
  • 2002
VIEW 7 EXCERPTS
CITES BACKGROUND, RESULTS & METHODS
HIGHLY INFLUENCED

References

Publications referenced by this paper.
SHOWING 1-10 OF 46 REFERENCES

Similar Papers

Loading similar papers…