Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.

@article{Rao2009DecreasedGB,
  title={Decreased GRK3 but not GRK2 expression in frontal cortex from bipolar disorder patients.},
  author={Jagadeesh Sridhara Rao and Stanley I. Rapoport and Hyungwook Kim},
  journal={The international journal of neuropsychopharmacology},
  year={2009},
  volume={12 6},
  pages={851-60}
}
Overactivation of G-protein-mediated functions and altered G-protein regulation have been reported in bipolar disorder (BD) brain. Further, drugs effective in treating BD are reported to up-regulate expression of G-protein receptor kinase (GRK) 3 in rat frontal cortex. We therefore hypothesized that some G-protein subunits and GRK levels would be reduced in the brain of BD patients. We determined protein and mRNA levels of G-protein beta and gamma subunits, GRK2, and GRK3 in post-mortem frontal… CONTINUE READING
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