Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart.

@article{Paternostro1995DecreasedGM,
  title={Decreased GLUT-4 mRNA content and insulin-sensitive deoxyglucose uptake show insulin resistance in the hypertensive rat heart.},
  author={Giovanni Paternostro and Kieran Clarke and J. S. Heath and Anne Marie L Seymour and George K. Radda},
  journal={Cardiovascular research},
  year={1995},
  volume={30 2},
  pages={205-11}
}
OBJECTIVES Insulin resistance in skeletal muscle and adipose tissue often accompanies hypertension; however, it has not been shown that heart muscle is similarly affected. The aims of this study were to determine whether basal and insulin-stimulated glucose transport and glucose transporter mRNA content are altered in the spontaneously hypertensive rat (SHR) heart. METHODS Hearts from 16-18-month-old SHRs were compared to their normotensive (WKY) controls. The accumulation of 2-deoxyglucose-6… CONTINUE READING