Decreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas

Abstract

PURPOSE Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often overexpressed in gastric carcinomas and during gastric carcinogenesis. However, little is known about the expression of 15… (More)
DOI: 10.3349/ymj.2008.49.6.917

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