Decreased DNA repair gene expression among individuals exposed to arsenic in United States drinking water.

Abstract

Arsenic is well established as a human carcinogen, but its precise mechanism of action remains unknown. Arsenic does not directly damage DNA, but may act as a carcinogen through inhibition of DNA repair mechanisms, leading indirectly to increased mutations from other DNA damaging agents. The molecular mechanism underlying arsenic inhibition of nucleotide… (More)

Topics

5 Figures and Tables

Slides referencing similar topics