Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.

@article{Hjkov2012DecreasedDM,
  title={Decreased DNA methylation in acute myeloid leukemia patients with DNMT3A mutations and prognostic implications of DNA methylation.},
  author={Hana H{\'a}jkov{\'a} and Jana Markov{\'a} and Cedrik Ha{\vs}kovec and Iveta S{\'a}rov{\'a} and Ota Fuchs and Arno{\vs}t Koste{\vc}ka and Petr Cetkovsk{\'y} and Kyra Michalov{\'a} and Jiř{\'i} Schwarz},
  journal={Leukemia research},
  year={2012},
  volume={36 9},
  pages={1128-33}
}
We examined 79 acute myeloid leukemia (AML) patients for DNA methylation of 12 tumor suppressor genes (TSG) and 24 homeobox domain (Hox) genes, and additionally for mutations in DNMT3A gene. We observed lower levels of DNA methylation (P<0.0001) as well as smaller numbers of concurrently hypermethylated genes (P<0.0001) in patients with DNMT3A mutations. Our study of the impact of DNA methylation on prognosis in intermediate and high risk AML patients revealed a relation between higher DNA… CONTINUE READING

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