Decreased Binding of 14C-Homogentisic Acid induced by Ascorbic Acid in Connective Tissues of Rats with Experimental Alcaptonuria

Abstract

ADULTS with alcaptonuria develop a destructive arthritis secondary to the deposition of a melanin-like pigment in their connective tissues, especially skin, tendon and Cartilage (ochronosis). The biochemical steps leading to ochronosis involve the chemical binding of oxidized and/or polymerized derivatives of homogentisic acid (HGA), the metabolite… (More)
DOI: 10.1038/228770a0

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