Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease.

@article{Itoh2001DecreasedBE,
  title={Decreased Bax expression by mucosal T cells favours resistance to apoptosis in Crohn's disease.},
  author={Jugoh Itoh and Carol A. de la Motte and Scott A. Strong and Alan D. Levine and Carina Fiocchi},
  journal={Gut},
  year={2001},
  volume={49 1},
  pages={35-41}
}
BACKGROUND Activated T cells are more susceptible to apoptosis than resting T cells. As intestinal T cells normally exhibit a higher state of activation, increased apoptosis may be necessary to maintain immune homeostasis in the specialised microenvironment of the mucosa. On the other hand, in Crohn's disease (CD) mucosal T cells are resistant to apoptosis, suggesting abnormal regulation of cell death mechanisms. AIMS To investigate differences in expression of anti- and proapoptotic Bcl-2… CONTINUE READING

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Resistance of Crohn ’ s disease T - cells to multiple apoptotic stimuli is associated with a Bcl - 2 / Bax mucosal imbalance

K Ina, J Itoh, K Fukushima
J Immunol • 1999

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