Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure.

@article{Martin2007DecreasedA,
  title={Decreased ADAMTS-13 (A disintegrin-like and metalloprotease with thrombospondin type 1 repeats) is associated with a poor prognosis in sepsis-induced organ failure.},
  author={Kenneth Martin and Delphine Borgel and Nicolas Lerolle and H B Feys and Ludovic Trinquart and Karen Vanhoorelbeke and Hans Deckmyn and Paulette Legendre and J E Diehl and Dominique Baruch},
  journal={Critical care medicine},
  year={2007},
  volume={35 10},
  pages={2375-82}
}
OBJECTIVE The inability to regulate the inflammatory response initiated upon infection leads to severe sepsis, characterized by widespread microvascular injury and thrombosis, organ ischemia, and dysfunction. A disintegrin-like and metalloprotease with thrombospondin type 1 repeats (ADAMTS)-13 regulates primary hemostasis by proteolyzing von Willebrand factor (VWF). Decreased ADAMTS-13 has been reported in disseminated intravascular coagulation due to severe sepsis. The present study… CONTINUE READING

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