Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage.

@article{Zheng2002Decreased5C,
  title={Decreased 5alpha-dihydrotestosterone catabolism suppresses T lymphocyte functions in males after trauma-hemorrhage.},
  author={Rui Zheng and T. S. Anantha Samy and Christian P. Schneider and Loring W. Rue and Kirby I. Bland and Irshad H. Chaudry},
  journal={American journal of physiology. Cell physiology},
  year={2002},
  volume={282 6},
  pages={C1332-8}
}
Trauma-hemorrhage produces profound immunosuppression in males but not in proestrus females. Prior castration or flutamide treatment of males following trauma-hemorrhage prevents immunosuppression, implicating 5alpha-dihydrotestosterone for the immunosuppressive effects. 5alpha-dihydrotestosterone, a high-affinity androgen receptor-binding steroid, is synthesized in tissues as needed and seldom accumulates. The presence of steroidogenic enzymes in T lymphocytes suggests both synthesis and… CONTINUE READING
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