Decreased 5-HT2cR and GHSR1a interaction in antipsychotic drug-induced obesity.


Second generation antipsychotics (SGAs), notably atypical antipsychotics including olanzapine, clozapine and risperidone, can cause weight gain and obesity side effects. Antagonism of serotonin 2c receptors (5-HT2cR) and activation of ghrelin receptor type 1a (GHSR1a) signalling have been identified as a main cause of SGA induced obesity. Here we review the… (More)
DOI: 10.1111/obr.12638


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