Decrease of serum paraoxonase activity in chronic renal failure.

  title={Decrease of serum paraoxonase activity in chronic renal failure.},
  author={Thierry F Dantoine and Jean Debord and J P Charmes and Louis Merle and Pierre Marquet and G{\'e}rard Lach{\^a}tre and Claude Leroux-Robert},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={9 11},
Paraoxonase is an esterase that hydrolyzes organophosphate compounds. The enzyme is associated with HDL and could protect LDL against peroxidation, which suggests a possible involvement of paraoxonase in the antiatherogenic properties of HDL. Paraoxonase activity has been shown to be low in patients with myocardial infarction, diabetes mellitus, or familial hypercholesterolemia. Because cardiovascular disease is the main cause of death in chronic renal failure, serum paraoxonase activity was… CONTINUE READING