Decrease of peripheral large granular lymphocytes in Graves' disease.

  title={Decrease of peripheral large granular lymphocytes in Graves' disease.},
  author={Yoshinori Iwatani and Nobuyuki Amino and Osamu Kabutomori and Hidenori Mori and Hiroya Tamaki and Shigehiro Motoi and Y Izumiguchi and Katsumi Miyai},
  journal={Clinical and experimental immunology},
  volume={55 1},
Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients with thyrotoxic Graves' disease (GD), both the percentage (11.5 +/- 2.7%; n = 12; P less than 0.001) and the absolute count (244 +/- 102/mm3; P less than 0.01) of LGL were… CONTINUE READING