Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-κB pathway.

@article{Yang2012DecreaseOI,
  title={Decrease of intracellular chloride concentration promotes endothelial cell inflammation by activating nuclear factor-κB pathway.},
  author={Hui Yang and Lin-Yan Huang and De-Yi Zeng and Er-Wen Huang and Si-Jia Liang and Yong-Bo Tang and Ying-Xue Su and Jing Tao and Fei Shang and Qian-qian Wu and Li-Xiong Xiong and Xiaofei Lv and Jie Liu and Yong-Yuan Guan and Jia-guo Zhou},
  journal={Hypertension},
  year={2012},
  volume={60 5},
  pages={1287-93}
}
Recent evidence suggested that ClC-3 channel/antiporter is involved in regulation of nuclear factor (NF)-κB activation. However, the mechanism explaining how ClC-3 modulates NF-κB signaling is not well understood. We hypothesized that ClC-3-dependent alteration of intracellular chloride concentration ([Cl(-)](i)) underlies the effect of ClC-3 on NF-κB activity in endothelial cells. Here, we found that reduction of [Cl(-)](i) increased tumor necrosis factor-α (TNFα)-induced expression of… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 25 extracted citations

Blockade of Orai1 Store-Operated Calcium Entry Protects against Renal Fibrosis.

Journal of the American Society of Nephrology : JASN • 2016

References

Publications referenced by this paper.
Showing 1-10 of 39 references

Activation of volume regulated chloride channels protects myocardium from ischemia/reperfusion damage in second-window ischemic preconditioning.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2011

Similar Papers

Loading similar papers…