Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12.

@article{Till2005DecreaseOC,
  title={Decrease of carotid intima-media thickness in patients at risk to cerebral ischemia after supplementation with folic acid, Vitamins B6 and B12.},
  author={Uwe Till and Peter J. R{\"o}hl and Almut Jentsch and Heiko Till and Andreas M{\"u}ller and Klaus Bellstedt and Dietmar Plonn{\'e} and Horst S Fink and R. Vollandt and Ulrich Sliwka and Falko H. Herrmann and Henning Petermann and Reiner Riezler},
  journal={Atherosclerosis},
  year={2005},
  volume={181 1},
  pages={131-5}
}
OBJECTIVE Hyperhomocysteinemia is associated with atherosclerotic risk. Although vitamins can lower homocysteine (Hcy), information about effects on atherosclerosis is scarce. METHODS We used carotid intima-media thickness (IMT) as an accepted marker of atherosclerotic changes. Fifty patients (60 +/- 8 years) with IMT> or =1 mm were included. In a double blind, randomized trial they received daily 2.5 mg folic acid, 25 mg Vitamin B6, and 0.5mg Vitamin B12 or placebo for 1 year. RESULTS In… CONTINUE READING
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