Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells

@article{Ramer2010DecreaseOP,
  title={Decrease of Plasminogen Activator Inhibitor-1 May Contribute to the Anti-Invasive Action of Cannabidiol on Human Lung Cancer Cells},
  author={R. Ramer and Anja Rohde and J. Merkord and Helga Rohde and B. Hinz},
  journal={Pharmaceutical Research},
  year={2010},
  volume={27},
  pages={2162-2174}
}
ABSTRACTPurposeUsing human lung cancer cells, we evaluated the involvement of plasminogen activator inhibitor-1 (PAI-1) in the anti-invasive action of cannabidiol, a non-psychoactive cannabinoid.MethodsInvasion was quantified by a modified Boyden chamber assay. PAI-1 protein in cell culture media and PAI-1 mRNA were determined by immunoblotting and RT-PCR, respectively.ResultsCannabidiol caused a profound inhibition of A549 cell invasion, accompanied by a decreased expression and secretion of… Expand
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