Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN.

@article{Puissant2005DecreaseOL,
  title={Decrease of Lewis frequency in HIV-infected patients: possible competition of fucosylated antigens with HIV for binding to DC-SIGN.},
  author={B{\'e}n{\'e}dicte Puissant and Francis Roubinet and J{\'e}r{\^o}me Dellacasagrande and Patrice Massip and Michel Abbal and Christophe Pasquier and Jacques Izopet and Antoine Blancher},
  journal={AIDS},
  year={2005},
  volume={19 6},
  pages={
          627-30
        }
}
We explored the impact of human ABO glycosyltransferase and Lewis and secretor fucosyltransferase polymorphisms in HIV infection. We found that, compared with healthy blood donors, HIV-infected patients display a significant decrease in Le(a-b+) phenotype frequencies. We showed that HIV binding on DC-SIGN-transduced Jurkat cells was inhibited by fucosyl bovine serum albumin. Our results suggest a slight protective effect of Lewis b antigen on HIV infection, possibly by the competition of Lewis… CONTINUE READING
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