Decrease of CD4+CD25+ T cells in peripheral blood after liver transplantation: association with immunosuppression.

@article{Demirkiran2005DecreaseOC,
  title={Decrease of CD4+CD25+ T cells in peripheral blood after liver transplantation: association with immunosuppression.},
  author={Ahmet Demirkiran and Alice Kok and Jaap Kwekkeboom and Harold J. Metselaar and Hugo W G Tilanus and Luc J W van der Laan},
  journal={Transplantation proceedings},
  year={2005},
  volume={37 2},
  pages={1194-6}
}
CD25 (IL-2 receptor alpha-chain) marks a population of CD4-positive T cells with a suppressor phenotype. These CD4+CD25+ regulatory T cells can suppress both effector T cells and antigen-presenting cells and have been identified as a principle regulator of tolerance in experimental transplantation models. In the setting of human liver transplantation, however, little is known about the dynamics of these cells in relation to rejection, tolerance, and immunosuppression. In the current study we… CONTINUE READING

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