Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin.

@article{Haertter2012DecreaseIT,
  title={Decrease in the oral bioavailability of dabigatran etexilate after co-medication with rifampicin.},
  author={Sebastian Haertter and Michael K{\"o}nen-Bergmann and Ashish Sharma and Gerhard Nehmiz and Ute Lemke and Wolfgang Timmer and PaulA. Reilly},
  journal={British journal of clinical pharmacology},
  year={2012},
  volume={74 3},
  pages={
          490-500
        }
}
AIMS This study examined the effects of the CYP3A/P-glycoprotein inducer, rifampicin, on the pharmacokinetics of dabigatran following oral administration of the prodrug, dabigatran etexilate. METHODS This was an open-label, fixed-sequence, four-period study in healthy volunteers. Subjects received a single dose of dabigatran etexilate 150 mg on day 1, rifampicin 600 mg once daily on days 2-8, and single doses of dabigatran etexilate on days 9, 16 and 23. RESULTS Twenty-four subjects were… CONTINUE READING
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