Decrease in the number of neonatal islets required for successful transplantation by strict metabolic control of diabetic rats.

We have investigated the influence of glycemic control on the number of transplanted neonatal islets needed to cure streptozotocin (STZ)-diabetic rats. Intrasplenic transplantation of 1000 neonatal islets to a group of STZ-diabetic rats with poor glycemic control cured only 30% of the rats. In a second group, insulin at doses of 10-15 U/day given for 5 days… CONTINUE READING