Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride–intoxicated rats

@article{Liu1993DecreaseIT,
  title={Decrease in the hepatic clearance of hepatocyte growth factor in carbon tetrachloride–intoxicated rats},
  author={K. X. Liu and Yukio Kato and Masayo Yamazaki and Osamu Higuchi and T. Nakamura and Yuichi Sugiyama},
  journal={Hepatology},
  year={1993},
  volume={17}
}
To examine whether a decrease in hepatic uptake, clearance or both of hepatocyte growth factor contributes to increased plasma hepatocyte growth factor levels, we kinetically analyzed hepatic hepatocyte growth factor handling using rats with carbon tetrachloride–induced liver injury in both in vivo and perfused liver systems. After the intravenous administration of tracer 125I–hepatocyte growth factor, the time profile of trichloroacetic acid–precipitable 125I–hepatocyte growth factor was… 
Heparin‐hepatocyte growth factor complex with low plasma clearance and retained hepatocyte proliferating activity
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Existence of two nonlinear elimination mechanisms for hepatocyte growth factor in rats.
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Pharmacokinetics and Pharmacodynamics following Intravenous Administration of Recombinant Human Hepatocyte Growth Factor in Rats with Renal Injury
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The intravenous administration of HGF after the onset of renal dysfunction exerted a pharmacological effect on AKI, and renal injury did not affect the clearance of plasma HGF, indicating that HGF had a pharmacodynamic effect.
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Hepatocyte growth factor (hepatopoietin A) rapidly increases in plasma before DNA synthesis and liver regeneration stimulated by partial hepatectomy and carbon tetrachloride administration
TLDR
The concurrent elevation in plasma levels of the strongest hepatocyte mitogen (hepatocyte growth factor) and the strongest liver mitogenic amplifier (norepinephrine) probably serves to provide the mitogenic signal that initiates the first round of DNA synthesis during liver regeneration.
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TLDR
The findings indicate that the HGF-like factor in damaged liver of CCl4-treated rats is HGF and that liver itself can produce HGF when injured.
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TLDR
Serum human hepatocyte growth factor levels were measured using a newly developed enzyme‐linked immunosorbent assay kit in patients with liver diseases and the determination of the levels may be useful to differentiate fulminant and chronic types of hepatic failure.
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TLDR
The presence of control mechanisms governing HGF receptor function only in a regenerating organ after injury is suggested, suggesting that HGF may be a multifunctional growth factor, targeting to a variety of organs, and not restricted to liver.
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TLDR
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